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Dante Labs US Report

Diamond-Blackfan Anemia Report

$49.00
$49.00
Diamond-Blackfan anemia is a haematological disorder that affects the bone marrow, the site of production of blood cells. This rare form of congenital anemia prevents the proper maturation and production of red blood cells, resulting in a severe decrease in hemoglobin, the protein responsible for transporting oxygen to tissues. DBA occurs from birth or in the first months of life and is associated with congenital malformations and an increased risk of developing neoplasms, in particular myelodysplastic syndromes, acute myeloid leukemia and osteosarcoma.
Congenital malformations, which affect approximately half of DBA sufferers, include microcephaly, altered facial features, cardiac and renal abnormalities and hypospadias in males. Developmental delay may also appear.
Although this disease predominantly affects the red cell line, platelets and white blood cells may also occur in lower than normal concentrations.
DBA is caused by mutations in ribosomal proteins in about 80/85% of cases, giving rise to autosomal dominant inheritance. In the remaining cases, the mutations are sporadic (i.e. not inherited from a parent carrying a genetic anomaly), or linked to unknown genes.
Studies hypothesize that non-functioning ribosomes may increase the self-destruction of bone marrow cells (hence anemia), with the possible association of impaired regulation of cell division and apoptosis.
This report analyzes the main genes linked to the onset of Diamond-Blackfan anemia.

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Performing Scenarious

Receive within weeks digital results of your WGS test displayed in specific reports to help you better explore rare diseases.

Painless Sample Collection

Fast, simple and painless saliva collection kit included in the box.

What you get

  • Longevity and Wellness Report

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What is Whole Genome Sequencing?

Next-generation sequencing (NGS) techniques cross the labyrinth of genome complexity and enable transcription of the entire DNA. These technologies have achieved several goals such as workflow optimization, result customization, and data analysis and interpretation.

Dante Health's Whole Genome Sequencing is based on NGS, so it's the best starting point on the road to your health.

Specialized Genetic Counseling

Whenever you do analyzes, you may want to show the results to a specialist.

Find below the geneticist that best suits your needs here.

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The WGS test provides specific reports on how your DNA affects your life. But life is made up of much more: interests, passions, goals and everything you decide to be part of your daily life.

Dante Health knows the true value of all these aspects and offers you more detailed reports for every special part of you, for the price of a coffee.

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